Palmitic acid in the sn-2 position of dietary triacylglycerols does not affect insulin secretion or glucose homeostasis in healthy men and women.

ABSTRACT:

Background/objectives

Dietary triacylglycerols containing palmitic acid in the sn-2 position might impair insulin release and increase plasma glucose.

Subjects/methods

We used a cross-over designed feeding trial in 53 healthy Asian men and women (20-50 years) to test this hypothesis by exchanging 20% energy of palm olein (PO; control) with randomly interesterified PO (IPO) or high oleic acid sunflower oil (HOS). After a 2-week run-in period on PO, participants were fed PO, IPO and HOS for 6 week consecutively in randomly allocated sequences. Fasting (midpoint and endpoint) and postprandial blood at the endpoint following a test meal (3.54 MJ, 14 g protein, 85 g carbohydrate and 50 g fat as PO) were collected for the measurement of C-peptide, insulin, glucose, plasma glucose-

SUBMITTER: Filippou A 

PROVIDER: S-EPMC4155797 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature