Enantioselective carbocycle formation through intramolecular Pd-catalyzed allyl-aryl cross-coupling.

ABSTRACT: Aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products. The reaction is found to be quite general, affording 5, 6, and 7-membered carbocyclic products as single regioisomers and with moderate enantioselectivities. Examination of differential coupling partners points to rapid allyl-equilibration as a key stereodefining feature.

SUBMITTER: Schuster CH 

PROVIDER: S-EPMC4156259 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature