Determinants of successful glycemic control among participants in the BARI 2D trial: a post-hoc analysis.

ABSTRACT:

Objective

The BARI 2D trial compared insulin provision (IP) versus insulin sensitization (IS) for the primary outcome of total mortality in participants with T2DM and cardiovascular disease (CVD). In this analysis we examine baseline characteristics that are associated with successful long-term glycemic control.

Research design and methods

In a 2×2 factorial design, 2368 participants were randomized to either IP or IS therapy, and to either prompt revascularization with medical therapy or medical therapy alone. Successful long-term glycemic control (success) was defined by simultaneously meeting 1) a mean HbA1c level of <7.0% after each participant's third year of follow-up period, and 2) adherence with medications only from the assigned glycemic treatment arm during >80% of

SUBMITTER: Ismail-Beigi F 

PROVIDER: S-EPMC4156479 | biostudies-literature | 2014 Jan-Feb

REPOSITORIES: biostudies-literature