The blood-borne miRNA signature of lung cancer patients is independent of histology but influenced by metastases.

ABSTRACT:

Objectives

In our previous studies we reported a panel of 24 miRNAs that allowed discrimination between blood of lung tumor patients independent of the histological subtype and blood of healthy controls with an accuracy of 95.4% [94.9%-95.9%]. Here, we now separately analyzed the miRNA expression in blood of non-small cell lung cancer (NSCLC), including squamous cell lung cancer and adenocarcinoma, and small cell lung cancer (SCLC) patients.

Patients and methods

In total, we examined the expression levels of 1,205 miRNAs in blood samples from 20 patients from each of the three histological groups and determined differentially expressed miRNAs between histological subtypes and metastatic and non-metastatic lung cancer. We further determined the overlap of miRNAs expressed in

SUBMITTER: Leidinger P 

PROVIDER: S-EPMC4156643 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature