Characterisation of novel microRNAs in the Black flying fox (Pteropus alecto) by deep sequencing.

ABSTRACT:

Background

Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of infection. Host factors influencing viral replication are poorly understood in bats and are likely to include both pre- and post-transcriptional regulatory mechanisms. MicroRNAs are a major mechanism of post-transcriptional gene regulation, however very little is known about them in bats.

Results

This study describes 399 microRNAs identified by deep sequencing of small RNA isolated from tissues of the Black flying fox, Pteropus alecto, a confirmed natural reservoir of the human pathogens Hendra virus and Australian bat lyssavirus. Of the microRNAs identified, more t

SUBMITTER: Cowled C 

PROVIDER: S-EPMC4156645 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature