Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study.

ABSTRACT:

Introduction

MAPK genes are activated by a variety of factors related to growth factors, hormones, and environmental stress.

Methods

We evaluated associations between 13 MAPK genes and survival among 1,187 nonHispanic White and 1,155 Hispanic/Native American (NA) women diagnosed with breast cancer. We assessed the influence of diet, lifestyle, and genetic ancestry on these associations. Percent NA ancestry was determined from 104 Ancestry Informative Markers. Adaptive rank truncation product (ARTP) was used to determine gene and pathway significance.

Results

Associations were predominantly observed among women with lower NA ancestry. Specifically, the mitogen-activated protein kinases (MAPK) pathway was associated with all-cause mortality (P ARTP = 0.02), but not with

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC4156917 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature