Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet-induced obese rats.

ABSTRACT: Gastrointestinal weight-loss surgery (GIWLS) is currently the most effective treatment for severe obesity, with Roux en-Y gastric bypass (RYGB) among the best of the available surgical options. Despite its widespread clinical use, the mechanisms by which RYGB induces its profound weight loss remain largely unknown. This procedure effects weight loss by altering the physiology of weight regulation and eating behavior rather than by simple mechanical restriction and/or malabsorption as previously thought. To study how RYGB affects the physiology of energy balance, we developed a rat model of this procedure. In this report, we demonstrate that RYGB in diet-induced obese (DIO) rats induces a 25% weight loss, prolongs mean survival by 45%, and normalizes glucose homeostasis and lipid metabolism

SUBMITTER: Stylopoulos N 

PROVIDER: S-EPMC4157127 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature