Analytical strategies for discovery and replication of genetic effects in pharmacogenomic studies.

ABSTRACT: In the past decade, the pharmaceutical industry and biomedical research sector have devoted considerable resources to pharmacogenomics (PGx) with the hope that understanding genetic variation in patients would deliver on the promise of personalized medicine. With the advent of new technologies and the improved collection of DNA samples, the roadblock to advancements in PGx discovery is no longer the lack of high-density genetic information captured on patient populations, but rather the development, adaptation, and tailoring of analytical strategies to effectively harness this wealth of information. The current analytical paradigm in PGx considers the single-nucleotide polymorphism (SNP) as the genomic feature of interest and performs single SNP association tests to discover PGx effects -

SUBMITTER: Kohler JR 

PROVIDER: S-EPMC4157400 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature