Synthesis and Structural Characterization of 1-Arylimidazole-2-thiones and N,N'-Aryldiethoxyethylthioureas with Electronically Diverse Substituents: A Manifold of Hydrogen Bonding Networks.

ABSTRACT: The 1-arylimidazole-2-thiones, (Hmim^Ar) [Ar = 3,4,5-C₆H₂(OMe)₃, 2,4-C₆H₃(NO₂)(OMe), 2,4,6-C₆H₂Cl₃ and 3,5-C₆H₃(CF₃)₂], which feature electronically diverse substituents, may be obtained via acid-catalyzed ring closure of the corresponding N,N'-aryldiethoxyethylthiourea derivatives, ArN(H)C(S)N(H)CH₂CH(OEt)₂, (H₂detu^Ar), which in turn are obtained via treatment of aminoacetaldehyde diethyl acetal, H₂NCH₂CH(OEt)₂, with the respective arylisothiocyanates (ArNCS). The molecular structures of all of the above N,N'-aryldiethoxy

SUBMITTER: Palmer JH 

PROVIDER: S-EPMC4157683 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature