Altered serum microRNAs as novel diagnostic biomarkers for atypical coronary artery disease.

ABSTRACT:

Background and aim

Atypical coronary artery disease (ACAD) is characterized by atypical angina pectoris or silent myocardial ischemia. However, conventional diagnostic techniques are insufficient to identify this subtype of coronary atherosclerotic pathology, and specific and sensitive markers for diagnosing ACAD are still currently lacking. The aim of the present study is to identify a novel serum microRNA (miRNA) expression profile of ACAD patients and evaluate its clinical diagnostic value.

Patients and methods

127 patients who were diagnosed with ACAD and 54 age-matched controls were enrolled in this study. An initial screen of miRNA expression was performed in serum samples from 35 patients and 20 controls using TaqMan Low Density Array. A stem-loop quantitative reverse

SUBMITTER: Wang J 

PROVIDER: S-EPMC4157840 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature