The effect of disease on human cardiac protein expression profiles in paired samples from right and left ventricles.

ABSTRACT:

Background

Cardiac diseases (e.g. coronary and valve) are associated with ventricular cellular remodeling. However, ventricular biopsies from left and right ventricles from patients with different pathologies are rare and thus little is known about disease-induced cellular remodeling in both sides of the heart and between different diseases. We hypothesized that the protein expression profiles between right and left ventricles of patients with aortic valve stenosis (AVS) and patients with coronary artery disease (CAD) are different and that the protein profile is different between the two diseases. Left and right ventricular biopsies were collected from patients with either CAD or AVS. The biopsies were processed for proteomic analysis using isobaric tandem mass tagging and analyze

SUBMITTER: Littlejohns B 

PROVIDER: S-EPMC4158351 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature