Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk.

ABSTRACT: Human apurinic/apyrimidinic endonuclease 1 (APE1) functions mainly in DNA repair as an enzyme removing AP sites and in redox signaling as a coactivator of various transcription factors. Based on these multifunctions of APE1 within cells, numerous studies have reported that the alteration of APE1 could be a crucial factor in development of human diseases such as cancer and neurodegeneration. In fact, the study on the combination of an individual's genetic make-up with environmental factors (gene-environment interaction) is of great importance to understand the development of diseases, especially lethal diseases including cancer. Recent reports have suggested that the human carcinogenic risk following exposure to environmental toxicants is affected by APE1 alterations in terms of gene-enviro

SUBMITTER: Park JS 

PROVIDER: S-EPMC4158471 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature