Response to statin therapy in obstructive sleep apnea syndrome: a multicenter randomized controlled trial.

ABSTRACT:

Rationale

Accumulated evidence implicates sympathetic activation as inducing oxidative stress and systemic inflammation, which in turn lead to hypertension, endothelial dysfunction, and atherosclerosis in obstructive sleep apnea (OSA). Statins through their pleiotropic properties may modify inflammation, lipid profile, and cardiovascular outcomes in OSA.

Methods

This multicenter, randomized, double-blind study compared the effects of atorvastatin 40 mg/day versus placebo over 12 weeks on endothelial function (the primary endpoint) measured by peripheral arterial tone (PAT). Secondary endpoints included office blood pressure (BP), early carotid atherosclerosis, arterial stiffness measured by pulse wave velocity (PWV), and metabolic parameters.

Results

51 severe OSA pat

SUBMITTER: Joyeux-Faure M 

PROVIDER: S-EPMC4158472 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature