An assessment of the shared allelic architecture between type II diabetes and prostate cancer.

ABSTRACT:

Background

To determine whether the alleles that influence type II diabetes risk and glycemic traits also influence prostate cancer risk.

Methods

We used a multiple single-nucleotide polymorphisms (SNP) genotypic risk score to assess the average effect of alleles that increase type II diabetes risk or worsen glycemic traits on risk of prostate cancer in 19,662 prostate cancer cases and 19,715 controls from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium and 5,504 prostate cancer cases and 5,834 controls from the Cancer Research UK (CRUK) prostate cancer study.

Results

Calculating the average additive effect of type II diabetes or glycemic trait risk alleles on prostate cancer risk using a logistic

SUBMITTER: Yu OH 

PROVIDER: S-EPMC4158605 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature