Deep phenotyping of the unselected COPSAC2010 birth cohort study.

ABSTRACT:

Background

We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others.

Objective

The aim of this study is to explore these interactions by conducting a longitudinal study in an unselected cohort of pregnant women and their offspring with emphasis on deep clinical phenotyping, exposure assessment, and biobanking. Exposure assessments focus on the human microbiome. Nutritional intervention during pregnancy in randomized controlled trials are included in the study to prevent disease and to be able to establish causal relationships.

Methods

Pre

SUBMITTER: Bisgaard H 

PROVIDER: S-EPMC4158856 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature