The value of CT for disease detection and prognosis determination in combined pulmonary fibrosis and emphysema (CPFE).

ABSTRACT:

Background and purpose

Several imaging-based indices were constructed quantitatively using the emphysema index (EI) and fibrosis score (FS) on high-resolution computed tomography (HRCT). We evaluated the ability of these indices to predict mortality compared to physiologic results. Additionally, prognostic predictive factors were compared among subgroups with biopsy-proven fibrotic idiopathic interstitial pneumonia (IIP) (biopsy-proven CPFE) and in a separate cohort with subclinical CPFE.

Materials and methods

Three chest radiologists independently determined FS. EI was automatically quantified. PFTs, smoking history, and composite physiologic index (CPI) were reviewed. Predictors of time to death were determined based on clinico-physiologic factors and CT-based CPFE indices

SUBMITTER: Choi SH 

PROVIDER: S-EPMC4159339 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature