APTE: identification of indirect read-out A-DNA promoter elements in genomes.

ABSTRACT:

Background

Transcriptional regulation is normally based on the recognition by a transcription factor of a defined base sequence in a process of direct read-out. However, the nucleic acid secondary and tertiary structure can also act as a recognition site for the transcription factor in a process known as indirect read-out, although this is much less understood. We have previously identified such a transcriptional control mechanism in early Xenopus development where the interaction of the transcription factor ilf3 and the gata2 promoter requires the presence of both an unusual A-form DNA structure and a CCAAT sequence. Rapid identification of such promoters elsewhere in the Xenopus and other genomes would provide insight into a less studied area of gene regulation, although currentl

SUBMITTER: Whitley DC 

PROVIDER: S-EPMC4159511 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature