A Proteome-wide Domain-centric Perspective on Protein Phosphorylation.

ABSTRACT: Phosphorylation is a widespread post-translational modification that modulates the function of a large number of proteins. Here we show that a significant proportion of all the domains in the human proteome is significantly enriched or depleted in phosphorylation events. A substantial improvement in phosphosites prediction is achieved by leveraging this observation, which has not been tapped by existing methods. Phosphorylation sites are often not shared between multiple occurrences of the same domain in the proteome, even when the phosphoacceptor residue is conserved. This is partly because of different functional constraints acting on the same domain in different protein contexts. Moreover, by augmenting domain alignments with structural information, we were able to provide direct eviden

SUBMITTER: Palmeri A 

PROVIDER: S-EPMC4159644 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature