Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.

ABSTRACT:

Background

Individual differences in breast size are a conspicuous feature of variation in human females and have been associated with fecundity and advantage in selection of mates. To identify common variants that are associated with breast size, we conducted a large-scale genotyping association meta-analysis in 7169 women of European descent across three independent sample collections with digital or screen film mammograms.

Methods

The samples consisted of the Swedish KARMA, LIBRO-1 and SASBAC studies genotyped on iCOGS, a custom illumina iSelect genotyping array comprising of 211 155 single nucleotide polymorphisms (SNPs) designed for replication and fine mapping of common and rare variants with relevance to breast, ovary and prostate cancer. Breast size of each subject w

SUBMITTER: Li J 

PROVIDER: S-EPMC4159740 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature