Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits.

ABSTRACT:

Background

Harms and benefits of cancer screening depend on age and comorbid conditions, but reliable estimates are lacking.

Objective

To estimate the harms and benefits of cancer screening by age and comorbid conditions to inform decisions about screening cessation.

Design

Collaborative modeling with 7 cancer simulation models and common data on average and comorbid condition level-specific life expectancy.

Setting

U.S. population.

Patients

U.S. cohorts aged 66 to 90 years in 2010 with average health or 1 of 4 comorbid condition levels: none, mild, moderate, or severe.

Intervention

Mammography, prostate-specific antigen testing, or fecal immunochemical testing.

Measurements

Lifetime cancer deaths prevented and life-years gained (benefits);

SUBMITTER: Lansdorp-Vogelaar I 

PROVIDER: S-EPMC4160041 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature