Development and evaluation of a panel of filovirus sequence capture probes for pathogen detection by next-generation sequencing.

ABSTRACT: A detailed understanding of the circulating pathogens in a particular geographic location aids in effectively utilizing targeted, rapid diagnostic assays, thus allowing for appropriate therapeutic and containment procedures. This is especially important in regions prevalent for highly pathogenic viruses co-circulating with other endemic pathogens such as the malaria parasite. The importance of biosurveillance is highlighted by the ongoing Ebola virus disease outbreak in West Africa. For example, a more comprehensive assessment of the regional pathogens could have identified the risk of a filovirus disease outbreak earlier and led to an improved diagnostic and response capacity in the region. In this context, being able to rapidly screen a single sample for multiple pathogens in a single tu

SUBMITTER: Koehler JW 

PROVIDER: S-EPMC4160210 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature