From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination.

ABSTRACT: A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman's chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.

SUBMITTER: Oldenhuis NJ 

PROVIDER: S-EPMC4160272 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature