Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice.

ABSTRACT:

Background

Innate lymphoid cells (ILCs) play important roles in innate immunity and tissue remodeling via production of various cytokines and growth factors. Group 2 ILCs (ILC2s) were recently shown to mediate the immune pathology of asthma even without adaptive immunity. However, little is known about possible interactions between ILC2s and other immune cells. We sought to investigate the capacity of ILC2s to regulate effector functions of T cells.

Methods

We isolated ILC2s from the lungs of naïve mice. We cultured CD4(+) T cells with ILC2s in vitro and examined the functions of these cell types. The mechanisms were investigated using blocking antibodies and cells isolated from cytokine-deficient mice. For the in vivo study, we adoptively transferred ILC2s and CD4(+) T cell

SUBMITTER: Drake LY 

PROVIDER: S-EPMC4160406 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature