Gene sequences regulating the production of apoE and cerebral palsy of variable severity.

ABSTRACT:

Background

The apoE protein is the most important lipid transporter in the brain and has also been shown to have several regulatory functions in the central nervous system. The production of apoE is regulated by a number of genes and increases under certain conditions such as cerebral injury in adults.

Aims

Our aim was to study whether variations in genes regulating the expression of the APOE gene were associated with severity of cerebral palsy (CP).

Methods

Children enrolled in the Cerebral Palsy Register of Norway (CPRN) were invited to participate in this cross-sectional study; 281 of the invited 703 children (40%) returned swabs with buccal cells collected by parents. Six genetic variations thought to affect the production of apoE were genotyped and correlated wit

SUBMITTER: Lien E 

PROVIDER: S-EPMC4160538 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature