Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients.

ABSTRACT:

Purpose

NRF2 transcription factor is involved in modulation of various antioxidant and metabolic genes and, therefore, may modulate anti-carcinogenic potential. Association between polymorphisms of NRF2 and five NRF2-regulated genes and urinary bladder cancer (BC) risk was analyzed.

Methods

The study group included 244 BC patients, while the control group comprised 365 individuals with no evidence of malignancy. Genotyping of GSTM1 (deletion), GSTT1 (deletion), GSTA1 -69C/T (rs3957357), GSTP1 Ile105Val (rs1695), SOD2 Ala16Val (rs4880) and NRF2 -617C/A (rs6721961) in blood genomic DNA was performed by means of real-time PCR assays. The associations between gene polymorphism and BC risk were computed by logistic regression.

Results

The frequency of GSTA1, GSTP1, SOD2 an

SUBMITTER: Reszka E 

PROVIDER: S-EPMC4160566 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature