Design and Synthesis of Orally Bioavailable Benzimidazole Reverse Amides as Pan RAF Kinase Inhibitors.

ABSTRACT: Benzimidazole reverse amides were designed and synthesized as Pan RAF kinase inhibitors. Investigation of the structure-activity relationship of the compounds revealed that they were potent in vitro and exhibited desirable in vivo properties.

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC4160747 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature