Ontology highlight
ABSTRACT:
SUBMITTER: Giacomini E
PROVIDER: S-EPMC4160757 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20140708 9
Given our interest in finding potential antitumor agents and in view of the multifactorial mechanistic nature of cancer, in the present work, taking advantage of the multifunctional ligands approach, new chimeric molecules were designed and synthesized by combining in single chemical entities structural features of SAHA, targeting histone deacetylases (HDACs), with substituted stilbene or terphenyl derivatives previously obtained by us and endowed with antiproliferative and pro-apoptotic activit ...[more]