To "grow" or "go": TMEM16A expression as a switch between tumor growth and metastasis in SCCHN.

ABSTRACT:

Purpose

Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear. We examined TMEM16A (ANO1) expression as a key factor shifting tumors between growth and metastasis.

Experimental design

We evaluated 26 pairs of primary and metastatic lymph node (LN) tissue from patients with squamous cell carcinoma of the head and neck (SCCHN) for differential expression of TMEM16A. In addition, we identified mechanisms by which TMEM16A expression influences tumor cell motility via proteomic screens of cell lines and in vivo mouse studies of metastasis.

Results

Compared with primary tumors, TMEM16A expression decreases in metastatic LNs of patients with SCCHN. Stable reduction of TMEM16A expres

SUBMITTER: Shiwarski DJ 

PROVIDER: S-EPMC4160843 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature