Optical coherence tomography microangiography for monitoring the response of vascular perfusion to external pressure on human skin tissue.

ABSTRACT: Characterization of the relationship between external pressure and blood flow is important in the examination of pressure-induced disturbance in tissue microcirculation. Optical coherence tomography (OCT)-based microangiography is a promising imaging technique, capable of providing the noninvasive extraction of functional vessels within the skin tissue with capillary-scale resolution. Here, we present a feasibility study of OCT microangiography (OMAG) to evaluate changes in blood perfusion in response to externally applied pressure on human skin tissue in vivo. External force is loaded normal to the tissue surface at the nailfold region of a healthy human volunteer. An incremental force is applied step by step and then followed by an immediate release. Skin perfusion events including basel

SUBMITTER: Choi WJ 

PROVIDER: S-EPMC4160975 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature