Co-regulated transcripts associated to cooperating eSNPs define Bi-fan motifs in human gene networks.

ABSTRACT: Associations between the level of single transcripts and single corresponding genetic variants, expression single nucleotide polymorphisms (eSNPs), have been extensively studied and reported. However, most expression traits are complex, involving the cooperative action of multiple SNPs at different loci affecting multiple genes. Finding these cooperating eSNPs by exhaustive search has proven to be statistically challenging. In this paper we utilized availability of sequencing data with transcriptional profiles in the same cohorts to identify two kinds of usual suspects: eSNPs that alter coding sequences or eSNPs within the span of transcription factors (TFs). We utilize a computational framework for considering triplets, each comprised of a SNP and two associated genes. We examine pairs of

SUBMITTER: Kreimer A 

PROVIDER: S-EPMC4161301 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature