Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control.

ABSTRACT: Neuronal differentiation is exquisitely controlled both spatially and temporally during nervous system development. Defects in the spatiotemporal control of neurogenesis cause incorrect formation of neural networks and lead to neurological disorders such as epilepsy and autism. The mTOR kinase integrates signals from mitogens, nutrients and energy levels to regulate growth, autophagy and metabolism. We previously identified the insulin receptor (InR)/mTOR pathway as a critical regulator of the timing of neuronal differentiation in the Drosophila melanogaster eye. Subsequently, this pathway has been shown to play a conserved role in regulating neurogenesis in vertebrates. However, the factors that mediate the neurogenic role of this pathway are completely unknown. To identify downstream eff

SUBMITTER: Avet-Rochex A 

PROVIDER: S-EPMC4161320 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature