Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni.

ABSTRACT: Schistosomiasis is an infectious disease infecting mammals as the definitive host and fresh water snails as the intermediate host. Understanding the molecular and biochemical relationship between the causative schistosome parasite and its hosts will be key to understanding and ultimately treating and/or eradicating the disease. There is increasing evidence that pathogens that have co-evolved with their hosts can manipulate their hosts' behaviour at various levels to augment an infection. Bacteria, for example, can induce beneficial chromatin remodelling of the host genome. We have previously shown in vitro that Biomphalaria glabrata embryonic cells co-cultured with schistosome miracidia display genes changing their nuclear location and becoming up-regulated. This also happens in vivo in li

SUBMITTER: Arican-Goktas HD 

PROVIDER: S-EPMC4161332 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature