Gene expression profiling in Entamoeba histolytica identifies key components in iron uptake and metabolism.

ABSTRACT: Entamoeba histolytica is an ameboid parasite that causes colonic dysentery and liver abscesses in humans. The parasite encounters dramatic changes in iron concentration during its invasion of the host, with relatively low levels in the intestinal lumen and then relatively high levels in the blood and liver. The liver notably contains sources of iron; therefore, the parasite's ability to use these sources might be relevant to its survival in the liver and thus the pathogenesis of liver abscesses. The objective of the present study was to identify factors involved in iron uptake, use and storage in E. histolytica. We compared the respective transcriptomes of E. histolytica trophozoites grown in normal medium (containing around 169 µM iron), low-iron medium (around 123 µM iron), iron-deficien

SUBMITTER: Hernandez-Cuevas NA 

PROVIDER: S-EPMC4161402 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature