Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy.

ABSTRACT:

Background

Allergen-specific immunotherapy is the only mode of therapy that has been demonstrated to offer a cure in patients with IgE-mediated respiratory allergies.

Objective

We sought to demonstrate the safety and efficacy of timothy grass (TG) and dust mite (DM) dual sublingual immunotherapy (SLIT) and to begin to investigate the immune mechanisms involved in successful immunotherapy with multiple allergens.

Methods

The safety and efficacy of dual SLIT with TG and DM in children and adults with demonstrated allergies to TG and DM were investigated in a single-center, randomized, double-blind, controlled phase I study. Thirty subjects received either TG and DM dual SLIT (n= 20) or placebo (n = 10). Immune parameters were evaluated for differentiation of desensitize

SUBMITTER: Swamy RS 

PROVIDER: S-EPMC4161455 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature