1H-NMR metabolomic biomarkers of poor outcome after hemorrhagic shock are absent in hibernators.

ABSTRACT:

Background

Hemorrhagic shock (HS) following trauma is a leading cause of death among persons under the age of 40. During HS the body undergoes systemic warm ischemia followed by reperfusion during medical intervention. Ischemia/reperfusion (I/R) results in a disruption of cellular metabolic processes that ultimately lead to tissue and organ dysfunction or failure. Resistance to I/R injury is a characteristic of hibernating mammals. The present study sought to identify circulating metabolites in the rat as biomarkers for metabolic alterations associated with poor outcome after HS. Arctic ground squirrels (AGS), a hibernating species that resists I/R injury independent of decreased body temperature (warm I/R), was used as a negative control.

Methodology/principal findings

Male

SUBMITTER: Bogren LK 

PROVIDER: S-EPMC4161479 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature