Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction.

ABSTRACT:

Background

This study tests whether the genetic predictor (CHRNA5 nicotine receptor gene variants) and an environmental risk factor (partner smoking) interact in the prediction of smoking reduction.

Methods

Subjects were from a community-based, longitudinal study of women (n=1856) who smoked before pregnancy, and a randomized comparative effectiveness smoking cessation trial (n=1065). Smoking reduction was defined as the trajectory of self-reported smoking quantities over time in the observational study, and as the trajectory of alveolar CO levels in the cessation trial.

Results

In the pregnancy study, rs16969968 genotype and partner smoking status interacted such that the smoking reduction was lowest for expectant mothers with high genetic risk and partner smoking, a

SUBMITTER: Chen LS 

PROVIDER: S-EPMC4161618 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature