Prospective observational multicenter study to define a diagnostic algorithm for biliary candidiasis.

ABSTRACT:

Aim

To develop an algorithm to improve the diagnosis and treatment of patients with biliary candidiasis.

Methods

We performed a prospective study of 127 patients who underwent endoscopic retrograde cholangiopancreatography, for various biliary disorders, at 3 tertiary referral centers in Germany from July 2011 through July 2012 (ClinicalTrials.gov: NCT01109550). Bile, buccal, and stool samples were collected. When indicated, endoscopic transpapillary bile duct biopsies were performed to clarify the etiology of bile duct strictures and to prove invasive fungal infections.

Results

Candida species were detected in 38 of the 127 bile samples (29.9%). By multivariate analysis patients' age and previous endoscopic sphincterotomy were independent risk factors for biliary can

SUBMITTER: Lenz P 

PROVIDER: S-EPMC4161811 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature