Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.

ABSTRACT:

Background

The spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis compromises effective control of tuberculosis (TB) in Siberia. Early identification of drug-resistant isolates is, therefore, crucial for effective treatment of this disease. The aim of this study was to conduct drug susceptibility testing and identify mutations in drug resistance genes in clinical isolates of M. tuberculosis from some TB patients presenting for treatment in Siberia.

Methods

Thirty randomly selected clinical isolates of M. tuberculosis were obtained from the Novosibirsk Research Institute of Tuberculosis, Russia. Isolates were screened for drug resistance and characterized by variable number of tandem repeats (VNTR)-typing using 15 standard and

SUBMITTER: Dymova MA 

PROVIDER: S-EPMC4161839 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature