Orders of magnitude extension of the effective dynamic range of TDC-based TOFMS data through maximum likelihood estimation.

ABSTRACT: In a recent article, we derived a probability distribution that was shown to closely approximate that of the data produced by liquid chromatography time-of-flight mass spectrometry (LC/TOFMS) instruments employing time-to-digital converters (TDCs) as part of their detection system. The approach of formulating detailed and highly accurate mathematical models of LC/MS data via probability distributions that are parameterized by quantities of analytical interest does not appear to have been fully explored before. However, we believe it could lead to a statistically rigorous framework for addressing many of the data analytical problems that arise in LC/MS studies. In this article, we present new procedures for correcting for TDC saturation using such an approach and demonstrate that there is p

SUBMITTER: Ipsen A 

PROVIDER: S-EPMC4161928 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature