Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults.

ABSTRACT:

Objective

To examine the relationship between sleep quality and cortical and hippocampal volume and atrophy within a community-based sample, explore the influence of age on results, and assess the possible confounding effects of physical activity levels, body mass index (BMI), and blood pressure.

Methods

In 147 community-dwelling adults (92 female; age 53.9 ± 15.5 years), sleep quality was measured using the Pittsburgh Sleep Quality Index and correlated with cross-sectional measures of volume and longitudinal measures of atrophy derived from MRI scans separated by an average of 3.5 years. Exploratory post hoc analysis compared correlations between different age groups and included physical activity, BMI, and blood pressure as additional covariates.

Results

Poor sleep

SUBMITTER: Sexton CE 

PROVIDER: S-EPMC4162301 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature