IPF clinical trial design and endpoints.

ABSTRACT:

Purpose of review

There remains a dire need for therapies that impact the clinical course of patients with idiopathic pulmonary fibrosis (IPF). Indeed, there is a surge of interest in IPF therapeutics, with many candidate agents in various stages of development. Optimal design and implementation of the appropriate prospective clinical trials are essential to demonstrate clinical efficacy of promising drugs for the treatment of IPF. A key element in the success of such clinical trials is the choice of the best endpoint(s) to match the design of the study.

Recent findings

Although the results of many IPF clinical trials have been disappointing, these trials have provided valuable insights into the epidemiology and natural history of the disease and have sparked debate into the

SUBMITTER: Nathan SD 

PROVIDER: S-EPMC4162322 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature