Bioremediation in marine ecosystems: a computational study combining ecological modeling and flux balance analysis.

ABSTRACT: The pressure to search effective bioremediation methodologies for contaminated ecosystems has led to the large-scale identification of microbial species and metabolic degradation pathways. However, minor attention has been paid to the study of bioremediation in marine food webs and to the definition of integrated strategies for reducing bioaccumulation in species. We propose a novel computational framework for analysing the multiscale effects of bioremediation at the ecosystem level, based on coupling food web bioaccumulation models and metabolic models of degrading bacteria. The combination of techniques from synthetic biology and ecological network analysis allows the specification of arbitrary scenarios of contaminant removal and the evaluation of strategies based on natural or syntheti

SUBMITTER: Taffi M 

PROVIDER: S-EPMC4162388 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature