A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children.

ABSTRACT: With the development of sequencing technologies, the direct testing of rare variant associations has become possible. Many statistical methods for detecting associations between rare variants and complex diseases have recently been developed, most of which are population-based methods for unrelated individuals. A limitation of population-based methods is that spurious associations can occur when there is a population structure. For rare variants, this problem can be more serious, because the spectrum of rare variation can be very different in diverse populations, as well as the current nonexistence of methods to control for population stratification in population-based rare variant associations. A solution to the problem of population stratification is to use family-based association tests

SUBMITTER: Sha Q 

PROVIDER: S-EPMC4162402 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature