Human kallikrein-2 gene and protein expression predicts prostate cancer at repeat biopsy.

ABSTRACT:

Purpose

The human kallikrein-2 (hK2) protein and two single nucleotide polymorphism (SNPs) (rs2664155, rs198977) of the gene are associated with prostate cancer risk. We examined whether hK2 protein and gene SNPs predict prostate cancer at the time of repeat biopsy.

Methods

We prospectively offered a repeat biopsy to men with a negative prostate biopsy performed for a PSA >4.0 ng/mL or abnormal Digital Rectal Exam (DRE) between 2001-2005. We genotyped and measured serum hK2 levels in 941 men who underwent a repeat prostate biopsy. Logistic regression analyses were conducted to determine the significance of KLK2 SNPs and hK2 levels for predicting cancer at repeat biopsy.

Results

Of the 941 patients, 180 (19.1%) were found to have cancer. The rs198977 SNP was positively

SUBMITTER: Satkunasivam R 

PROVIDER: S-EPMC4162525 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature