Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine.

ABSTRACT:

Introduction

Intestinal chemosensory receptors and transporters are able to detect food-derived molecules and are involved in the modulation of gut hormone release. Gut hormones play an important role in the regulation of food intake and the control of gastrointestinal functioning. This mechanism is often referred to as "nutrient sensing". Knowledge of the distribution of chemosensors along the intestinal tract is important to gain insight in nutrient detection and sensing, both pivotal processes for the regulation of food intake. However, most knowledge is derived from rodents, whereas studies in man and pig are limited, and cross-species comparisons are lacking.

Aim

To characterize and compare intestinal expression patterns of genes related to nutrient sensing in mice, pig

SUBMITTER: van der Wielen N 

PROVIDER: S-EPMC4162619 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature