Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials.

ABSTRACT: Stem cell technology is a promising branch of regenerative medicine that is aimed at developing new approaches for the treatment of severely debilitating human diseases, including those affecting the central nervous system (CNS). Despite the increasing understanding of the mechanisms governing their biology, the application of stem cell therapeutics remains challenging. The initial idea that stem cell transplants work in vivo via the replacement of endogenous cells lost or damaged owing to disease has been challenged by accumulating evidence of their therapeutic plasticity. This new concept covers the remarkable immune regulatory and tissue trophic effects that transplanted stem cells exert at the level of the neural microenvironment to promote tissue healing via combination of immune modu

SUBMITTER: Giusto E 

PROVIDER: S-EPMC4162671 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature