The effect of tuberculosis treatment on virologic and immunologic response to combination antiretroviral therapy among South African children.

ABSTRACT:

Background

Many HIV-infected children are diagnosed with tuberculosis (TB), but the effect of TB treatment on virologic and immunologic response to combination antiretroviral therapy (cART) is not well documented.

Methods

Secondary analysis of a prospective cohort of cART-naive HIV-infected South African children aged 0-8 years initiating cART to assess the effect of TB treatment at the time of cART initiation on virologic suppression (HIV RNA < 50 copies/mL), virologic rebound (HIV RNA > 1000 copies/mL after suppression), and CD4 cell percent (CD4%) increase during the first 24 months of cART.

Results

Of 199 children (median age 2.1 years), 92 (46%) were receiving TB treatment at cART initiation. Children receiving and not receiving TB treatment at cART initiation ha

SUBMITTER: Soeters HM 

PROVIDER: S-EPMC4162748 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature