Cumulative HIV viremia and non-AIDS-defining malignancies among a sample of HIV-infected male veterans.

ABSTRACT:

Background

Research suggests that cumulative measurement of HIV exposure is associated with mortality, AIDS, and AIDS-defining malignancies. However, the relationship between cumulative HIV and non-AIDS-defining malignancies (NADMs) remains unclear. The aim of this study was to evaluate the effect of different HIV measures on NADM hazard among HIV-infected male veterans.

Methods

We performed a retrospective cohort study using Veterans Affairs HIV Clinical Case Registry data from 1985 to 2010. We analyzed the relationship between HIV exposure (recent HIV RNA, % undetectable HIV RNA, and HIV copy-years viremia) and NADM. To evaluate the effect of HIV, we calculated hazard ratios for 3 common virally associated NADM [ie, hepatocarcinoma (HCC), Hodgkin lymphoma (HL), and squamou

SUBMITTER: Kowalkowski MA 

PROVIDER: S-EPMC4162758 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature