Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension.

ABSTRACT: Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nucleus of the solitary tract/dorsal motor nucleus of the vagus), a key brain stem region for cardiovascular regulation, on the development of renovascular hypertension. Holtzman normotensive rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip renovascular hypertension. Three weeks later, rats were microinjected in the solitary-vagal complex with either an adeno

SUBMITTER: Blanch GT 

PROVIDER: S-EPMC4162765 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature