More than memory impairment in voltage-gated potassium channel complex encephalopathy.

ABSTRACT:

Background and purpose

Autoimmune encephalopathies (AEs) are a heterogeneous group of neurological disorders that affect cognition. Although memory difficulties are commonly endorsed, few reports of AEs inclusively assess all cognitive domains in detail. Our aim was to perform an unbiased cognitive evaluation of AE patients with voltage-gated potassium channel complex antibodies (VGKCC -Abs) in order to delineate cognitive strengths and weaknesses.

Methods

Serial VGKCC -Ab AE subjects (n = 12) were assessed with a comprehensive evaluation of memory, executive functions, visuospatial skills and language. Clinical magnetic resonance imaging (MRI) (n = 10/12) was evaluated. Five subjects had serial cognitive testing available, permitting descriptive analysis of change.

Resul

SUBMITTER: Bettcher BM 

PROVIDER: S-EPMC4162838 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature